Full opinion text
OPINION MARTINI, District Judge. Plaintiffs Daiichi Sankyo Company, Limited and Daiichi Sankyo, Inc. (collectively “Daiichi Sankyo”) are the inventors and producers of olmesartan medoxomil, the active ingredient in the hypertension medications Benicar, Benicar HCT, and Azor. Defendants Mylan Pharmaceuticals Inc., Mylan Laboratories Inc., Matrix Laboratories, LTD., and Mylan, Inc. (collectively “Mylan”) are drug manufacturers seeking to market a generic version of olmesartan medoxomil. Daiichi Sankyo filed this suit claiming infringement of its United States Patent No. 5,616,599 (“the '599 patent”). Mylan concedes infringement of the '599 patent, but counters that the '599 is invalid due to obviousness. Claim 13 of the '599 patent is the only claim at issue. The parties tried this case before the Court on various days from March 31, 2009 to April 20, 2009. Thereafter, they submitted proposed findings of fact and conclusions of law. The Court carefully considered the parties’ submission and the record evidence. For the reasons set forth below, the Court finds that Mylan has failed to prove by clear and convincing evidence that the '599 patent is obvious under 35 U.S.C. § 103(a). As a result, the '599 patent is neither invalid nor unenforceable. Mylan has infringed on the '599 patent under 35 U.S.C. § 271(e)(2). I. BACKGROUND Olmesartan medoxomil is the active ingredient in several medications produced by Daiichi Sankyo used for the treatment of hypertension. (Stipulation of Fact (“SF”) ¶ 13.) Hypertension, or high blood pressure, is one of the world’s leading causes of death. (Brown 4/2/09 Tr. JA 282:20-22.) Approximately seventy-three million people in the United States age twenty and older suffer from high blood pressure, with roughly sixty-two percent of this group receiving treatment. (Boghigian 4/8/09 Tr. JA 873:9-18; JA 5275.) Hypertension contributes to stroke, myocardial infarction, and other life-threatening conditions. (Brown 4/2/09 Tr. JA 282:6-10; Carey 4/14/09 Tr. JA 1009:5-9.) A. The Renin-Angiotensin System and Early Angiotensin Receptor Blockers Starting in the 1970s, scientists began to understand the role of the reninangiotensin system (“RAS” in controlling hypertension.) (Brown 4/2/09 Tr. JA 279:1-JA 281:21; DTX 356-B, at JA 5175-81, 5171 & 5197-200.) Angiotensin II, a peptide produced by the RAS, binds to ATX receptors, which are found on the surfaces of a variety of cell types including blood vessels and renal tubules. (Id.) The constriction caused by the binding of the angiotensin II to the ATi receptors leads to increased blood pressure. (Id.) By the late 1970s, scientists developed angiotensin converting enzyme inhibitors (“ACE” inhibitors), which directly interfered with the production of angiotensin II. (Brown 4/2/09 Tr. JA 282:22-284:5.) While ACE inhibitors proved effective, these compounds resulted in certain unwanted side-effects. (Cohn 4/7/09 Tr. JA 784:11-JA 785:23.) In 1982, a Japanese pharmaceutical company, Takeda Chemical Industries Ltd. (“Takeda”), developed the first non-peptide compounds, which blocked the binding of angiotensin II to ATX receptors. (Brown 4/2/09 Tr. JA 284:10-285:16; Weinstock 3/31/09 Tr. JA 96:14-97:10.) Termed angiotensin II receptor blockers (“ARBs”), these Takeda compounds contained an imidazole ring — a five membered ring having two nitrogen atoms. (Weinstock 3/31/09 Tr. JA 101:4-102:7; DTX 125, at JA 4164.) One early Takeda compound, known as S-8307, employed a single six-membered phenyl ring through a methylene linkage (CH2) at the 1-position of the imidazole ring, a butyl group at the 2-position, a chlorine atom (Cl) at the 4-position, and an acetic acid (CH2COOH) at the 5-position. (Weinstock 3/31/09 Tr. JA 102:10-20, 104:10-106:3; DTX 356-A, at JA 5127, 5130-32.) Figure 1 Chemical Structure of S-8307. (DTX 356-A, at JA 5132.) Although the first of its kind, the Takeda compounds exhibited limited therapeutic value due to a lack of oral activity. (Weinstock 3/31/09 Tr. JA 100:7-8.) B. Losarían Using Takeda’s work as lead, E.I. du Pont de Nemours Company, Inc. (“DuPont”) embarked on its own ARB development program in 1982. (Id. at JA 95:23-96:1.) Several years later, in 1989, DuPont announced that it had selected one of its compounds, DuP 753, also known as losarían, for clinical trials. (Id. at JA 111:5-9.) Figure 2 Chemical Structure of Losarían. (DTX 356-A, at JA 5138.) Losarían resembled Takeda S-8307 in the sense that it retained the imidazole ring and the chlorine atom at the 4-position of the imidazole ring. The compound, however, differed through the addition of a biphenyl tetrazole — a six membered phenyl and a tetrazole — at the 1-position of the imidazole ring, as well as a hydroxymethyl at the 5-position. (DTX 356-A, at JA 5132, 5138.) As a result of these changes, losarían exhibited a ten-fold greater binding affinity and twenty-fold greater oral activity over the Takeda compounds. (Weinstock 03/31/09 Tr. JA 112:19-JA 113:8.) Losartan represented a “milestone,” becoming the first non-peptide ARB clinical candidate. (Id. at JA 111:5-9; PTX 190, at JA 10028.) DuPont disclosed losarían and several hundred structurally related ARB compounds in United States Patent No. 5,138,069 (“the '069 patent”). (Weinstock 3/31/09 Tr. JA 119:11-23; DTX 195, at JA 3602-746.) C. Development of Olmesartan Medoxomil Following DuPont’s success with losartan, more than twenty pharmaceutical companies established ARB research programs. (Lipinski 4/20/09 Tr. JA 1558:19-20.) Daiiehi Sankyo started its own program, in late 1989, using losarían as a reference. (Yanagisawa 4/17/09 Tr. JA 1424:10-12, 1457:1-5.) The company employed a team of scientists lead by Dr. Hiroaki Yanagisawa “to come up with a drug that had ten times the activity of losartan” with “long enough duration so as to be dosed once-a-day.” (Id. at JA 1422:10-20.) After testing several hundred compounds, Daiichi Sankyo discovered the chemical compound olmesartan. (Id. at JA 1447:5-6; PTX 202-A, at JA 10499, 10256-498.) Dissatisfied with the compound’s oral absorption, Daiichi Sankyo attempted to improve olmesartan’s properties by attaching various ester promoieties to the chemical, converting olmesartan into the prodrug olmesartan medoxomil. (Yanagisawa 4/17/09 Tr. JA 1442:25-1446:1; PTX 26, at JA 9548-63.) The company discovered that a medoxomil ester at the 5-position of the imidazole ring led to a compound with 100 times the potency of losartan on oral administration. The medoxomil ester also crystallized, an “important factor in [a drug’s] manufacturing, its formulation and in quality assurance.” (Yanagisawa 4/17/09 Tr. JA 1445:20-23.) Based on this research, on April 26, 1991, Daiichi Sankyo filed a patent application in Japan, and subsequently in the United States, claiming olmesartan and olmesartan medoxomil. (SF ¶ 8; PTX 1, at JA 5611.) This led to the issuance the '599 patent by the United States Patent and Trademark Office (“PTO”) on April 1, 1997, with Claim 13 specifically covering olmesartan medoxomil. (SF ¶¶ 6, 11; PTX 1, at JA 5610.) Like losartan and the early Takeda compounds, olmesartan medoxomil retained an imidazole backbone and possessed a biphenyl tetrazole at the 1-position of the imidazole ring. (PTX 1, JA 5610-11.) Figure 3 Chemical Structure of Olmesartan Medoxomil. (DTX 356-A, at JA 5145.) However, olmesartan medoxomil differed from losartan in two major respects. First, at the 4-position of the imidazole ring, olmesartan medoxomil employed a hydroxyisopropyl (C(CH3)2OH) instead of a chlorine atom. (Weinstock 3/31/09 Tr. JA 121:11-17,125:6-127:1 & 129:3-5; DTX 356-A, at JA 5143, 5146.) Second, the compound contained a medoxomil ester linked to a carboxylic acid at the 5-posi-tion. (Weinstock 3/31/09 Tr. JA 121:1-10; DTX 356-A, at JA 5143, 5146.) D. DuPont’s '902 Patent Compounds and DuP 532 DuPont itself continued to look for improvements to losartan prior to Daiichi Sankyo’s April 26, 1991 patent application in Japan. (Hieble 4/7/09 Tr. JA 711:17-23.) This additional research led to the disclosure of the '902 patent compounds, as well as DuP 532. Following the disclosure of the '069 patent compounds, DuPont revealed six additional compounds in United States Patent No. 5,137,902 (“the '902 patent”) with a February 4, 1991 priority date. (DTX 96, at JA 3747-52.) A “culmination of DuPont’s ARB research,” the '902 patent compounds utilized losartan’s biphenyl-tetrazoleimidazole structure and contained a straight-chain propyl at the 2-position of the imidazole ring. (Weinstock 3/31/09 Tr. JA 119:24-120:12; DTX 96, at JA 3748.) Examples 1, 2, and 6 of the '902 patent compounds use a carboxylic acid at the 5-position, while Examples 3, 4, and 5 employ an aldehyde (CHO). (Lipinski 4/20/09 Tr. JA 1616:1-2.) At the 4-position of the imidazole ring, the '902 patent compounds contain various branched alkyls, including an ethyl, methyl, t-butyl, and isopropyl. (DTX 356-A, at JA 5143.) Although DuPont ultimately chose not to commercialize the '902 patent compounds, the most preferred '902 patent compounds exhibited oral activity “approximately 2 to 4 fold higher than most active compound specifically disclosed [in the '069 patent] which have been tested.” (Brown 4/2/09 Tr. JA 405:14-16; DTX 96, at JA 3748.) In mid-April 1991, DuPont also reported DuP 532, as part of its “new series of 4-perfluoro-alkylimidazole.” (PTX 244, at JA 10761-762; PTX 246, at JA 10765-766; Weinstock 4/6/09 Tr. JA 517:3-22; Timmermans 4/16/09 Tr. JA 1383:13-1384:16; Lipinski 4/20/09 Tr. JA 1573:24-1575:3, 1576:24-1577:15.) DuPont used losartan’s biphenyl-tetrazole-imidazole structure for DuP 532, but changed the 4-position of losartan from a chlorine atom to a substituent containing multiple fluorine atoms (CF2CF3). (Weinstock 4/1/09 Tr. JA 213:3-6; 4/6/09 Tr. JA 517:19-22.) Unlike losartan’s hydroxymethyl at the 5-position, DuP 532 employed a carboxylic acid (COOH). (Weinstock 3/31/09 Tr. JA 115:2-14; DTX 356-A at JA 5138, 5140.) Figure 5 Chemical Structure of DuP 532. (PTX 175, at JA 9907.) Through these changes, DuPont improved upon the oral activity of losartan. DuP 532 exhibited a three-fold increase in oral activity when compared to the company’s breakthrough drug. (Timmermans 4/16/09 Tr. JA 1391:12-16; Lipinski 4/20/09 Tr. JA 1577:11-15.) E. Other “Second Generation” ARBs Daiichi Sankyo and DuPont were not alone in their respective quests to develop compounds superior to losartan. By April 1991, several other large pharmaceutical companies contemporaneously developed their own “second generation” ARBs. Merck & Co. (“Merck”) revealed L-158,-809. Ciba-Geigy, Ltd. (“Ciba-Geigy”) developed valsarían. Eisai Co. Ltd. (“Eisai”) released information about a series of compounds, including E-4177 and Takeda disclosed candesartan cilexetil. (Weinstock 3/31/09 Tr. JA 48:6-9, 50:21-51:10, 62:2-5 & 63:1.) The structure of these “second generation” ARBs differed from the early Takeda compounds, losartan, and olmesartan medoxomil. Several of these drugs did not utilize an imidazole ring: L-158,809 and E-4177 used an imidazopyridine ring, candesartan cilexetil employed a benzimidazole ring, and valsarían lacked any ring whatsoever. (PTX 248, at JA 10769-770, PTX 250, at JA 10773-813.) These compounds also differed at the position corresponding to the 2-position of the imidazole ring: E-4177 utilized a hydrocarbon ring, while cyclopropyl and candesartan cilexetil contained a non-hydrocarbon carbon chain ethyoxy. (DTX 99, at JA 3753-94; PTX 250, at JA 10773-813.) F. Commercialization of Olmesartan Medoxomil and Other ARBs As a result of this extensive pharmaceutical x-esearch, seven ARBs have been released for public consumption. (Boghigian 4/8/09 Tr. JA 873:25-874:2.) Daiichi Sank-yo commercialized olmesartan medoxomil in three products, specifically Benicar and two combination drugs Benicar HCT and Azor. (SF ¶¶ 17-19.) At the time of Benicar’s launch in 2002, six other ARBs in the drug’s class had hit the market. (Boghigian 04/8/09 Tr. JA 874:11-12.) The oldest drug, Cozaar (losarían), manufactured by DuPont and then Merck, had been available for seven years, while the newest drug Teveten, manufactured by Abbott Laboratories, had been on the market for roughly two years. (PTX 584, at JA 25089.) In its first year, Benicar enjoyed $22.5 million in gross sales. (PTX 590-1, at JA 25092.) By 2008, the combined gross sales of Benicar, Benicar HCT, and Azor reached $1.3 billion. (Id.) During the same time, Benicar’s market share grew to 16.6%, making it the third largest ARB on the market. (PTX 583, at JA 25088.) G. Mylan’s Abbreviated New Drug Applications and the Current Litigation Following Daiichi Sankyo’s success with Benicar and the combination drugs, Mylan submitted several Abbreviated New Drug Applications (“ANDA”), seeking approval to manufacture and sell generic versions of Benicar, Benicar HCT, and Azor. (SF ¶¶ 21-23.) In conjunction with each ANDA, Mylan filed a certification under 21 U.S.C. 355(j)(2)(A)(vii)(IV), commonly referred to as a “Paragraph IV certification.” (Id. 24.) These certifications stated that, in Mylan’s “opinion and to the best of [their] knowledge, [the '599 patent is] invalid, unenforceable or will not be infringed by the manufacture, use, sale, offer for sale, or importation of [Mylan’s ANDA products].” (Id.) After filing each Paragraph IV certification, Mylan sent a Paragraph IV Notice Letter to Daiichi Sankyo alleging that Mylan’s ANDA products will not infringe any valid claim of the '599 patent. (Id. 25.) Each Notice Letter affirmed that Mylan provided the factual and legal bases, known by the company at that time, that no valid claim of the '599 patent would be infringed, either literally or under the doctrine of equivalents, by the commercial manufacture, use, or sale of Mylan’s ANDA products prior to the expiration of the '599 patent. (Id.) After receiving Notice Letters for Benicar, Benicar HCT, and Azor, Daiichi Sankyo filed three separate actions against Mylan, each within the relevant 45-day statutory time period. (Id. ¶ 25.) These actions have been consolidated for all purposes under the present matter. (Id. ¶ 26.) II. JURISDICTION, VENUE, AND APPLICABLE LAW This Court has subject matter jurisdiction over Daiichi Sankyo’s patent infringement claims and Mylan's counterclaims pursuant to 28 U.S.C. §§ 1331 and 1338(a). Since this action arises under the patent laws of the United States, the Court must apply the precedents of the United States Court of Appeals for the Federal Circuit, which has jurisdiction over any appeal of this judgment. See 28 U.S.C. § 1295(a). III. CONCLUSIONS OF LAW A. Standard for Obviousness Under the United States Patent Act, an invention cannot be patented if “the subject matter as a whole would have been obvious at the time the invention was made to a person having ordinary skill in the art to which said subject matter pertains.” 35 U.S.C. § 103(a). Since patents are presumed to be valid, Kao Corp. v. Unilever U.S., Inc., 441 F.3d 963, 968 (Fed.Cir.2006), the party seeking to invalidate a patent based on obviousness must demonstrate “by clear and convincing evidence that a skilled artisan would have been motivated to combine the teachings of the prior art references to achieve the claimed invention, and that the skilled artisan would have had a reasonable expectation of success in doing so.” Pfizer, Inc. v. Apotex, Inc., 480 F.3d 1348, 1361 (Fed.Cir.2007). Clear and convincing evidence places in the fact finder “an abiding conviction that the truth of [the] factual contentions are ‘highly probable.’ ” Colorado v. New Mexico, 467 U.S. 310, 316, 104 S.Ct. 2433, 81 L.Ed.2d 247 (1984) (citation omitted). The obviousness determination turns on underlying factual inquiries involving: (1) the scope and content of the prior art, (2) the level of ordinary skill in the art, (3) the differences between the claimed invention and the prior art, and (4) secondary considerations, such as commercial success and satisfaction of a long felt need. Graham v. John Deere Co., 383 U.S. 1, 17-18, 86 S.Ct. 684, 15 L.Ed.2d 545 (1966). In cases involving chemical compounds, the patent challenger may establish a prima facie case of obviousness if the party “identifies] some reason that would have led a chemist to modify a known compound in a particular manner.... ” Takeda Chem. Indus., Ltd. v. Alphapharm Pty., Ltd., 492 F.3d 1350, 1357 (Fed.Cir.2007). If a patent challenger makes a prima facie showing of obviousness, the patent owner may rebut based on “unexpected results” by demonstrating “that the claimed invention exhibits some superior property or advantage that a person of ordinary skill in the relevant art would have found surprising or unexpected.” In re Sony, 54 F.3d 746, 750 (Fed.Cir.1995). B. Level of Ordinary Skill in the Art The Court must first determine the level of ordinary skill in the art at the time of the filing of the '599 patent. Obviousness is judged from the perspective of a hypothetical person of ordinary skill in the art. Interconnect Planning Corp. v. Feil, 774 F.2d 1132, 1138 (Fed.Cir.1985). The hypothetical person must be viewed as an “inventor working in his [or her] shop with the prior art references — which he [or she] is presumed to know — hanging on the walls around him [or her].” Union Carbide Corp. v. Am. Can Co., 724 F.2d 1567, 1567 (Fed.Cir.1984). Such an individual possesses “ordinary creativity” and is not “an automaton.” KSR Int’l Co. v. Teleflex Inc., 550 U.S. 398, 420-21, 127 S.Ct. 1727, 167 L.Ed.2d 705 (2007). In cases where the level of skill is high, courts may “assume a keener appreciation of the nuances taught by the prior art.” McGinley v. Franklin Sports, Inc., 262 F.3d 1339, 1351 (Fed.Cir.2001). Here, the pertinent field of art is the design, development, synthesis, and testing of ARBs prior to the priority date of the '599 patent, April 26, 1991. (Weinstock 3/31/09 Tr. JA 124:7-125:5.) The parties agree that a person of ordinary skill is an experienced medicinal chemist with the ability to analyze structure-activity relationships (“SAR”). (Id.) Not only would a person of ordinary skill possess the ability to design, evaluate, and synthesize compounds, but such an individual would be able to evaluate pharmacological data obtained from routine screening assays. (Id. at JA 124:7-21.) C. Scope and Content of the Prior Art 1. The Prior Art at the Time of the Filing of the '599 Patent Under Graham, the Court must next define the scope and content of the prior art as of April 26, 1991. Prior art is limited to “analogous” references “from the same field or endeavor” or, if not, from the same field or endeavor art that is “reasonably pertinent to the particular problem with which the inventor is involved.” In re Bigio, 381 F.3d 1320, 1325 (Fed.Cir.2004). “When the references are all in the same or analogous fields, knowledge thereof by the hypothetical person of ordinary skill is presumed ... and the test is whether the teachings of the prior art, taken as a whole, would have made obvious the claimed invention.” In re Gorman, 933 F.2d 982, 986 (Fed.Cir.1991) (citation omitted). In the instant matter, the prior art includes DuPont’s '069 patent and '902 patent, as well as the thirteen scientific publications documenting DuPont’s work. The prior art also incorporates the various compounds disclosed in the '069 and '902 patents, which share olmesartan medoxomil’s chemical “backbone” — an imidazole ring with a biphenyl tetrazole at the 1-position and a straight chain alkyl at the 2-position. Additionally, the prior art encompasses patents related to other second generation ARB compounds published before April 26, 1991, such as Merck’s L-158,809, compounds disclosed by Eisai on April 13, 1991 in patent EP 0 420 237 B1 (the “Eisai compounds”), candesartan cilexetil, and valsarían. (PTX 247, at JA 10767-768; PTX 250, at JA 10773-813; DTX 99, at JA 03753-794; PTX 204, at JA 10500-532.) 2. Whether the Prior Ail “Taught Away” From the Use of a Hydrophilic Substituent The parties disagree as to whether the prior art, as a whole, “taught away” from the use of a hydrophilic, as opposed to lipophilic, substituent at the 4-position of the imidazole ring. Whether prior art teaches away or toward a claimed invention is a finding of fact that is a “subsidiary requirement” of the “scope and content of the prior art.” Ortho-McNeil Pharm., Inc. v. Kali Labs., Inc., 482 F.Supp.2d 478, 516 (D.N.J.2007) (citing DyStar Textilfarben GmbH v. C.H. Patrick Co., 464 F.3d 1356, 1360 (Fed.Cir.2006)). When the prior art “teaches away” from a particular combination of known elements, the successful combination of those elements is less likely to be obvious. E.I. Du Pont de Nemours & Co. v. MacDermid, Inc., Civ. No. 06-3383, 2008 WL 4952450, at *26 (D.N.J. Nov. 19, 2008) (citing KSR Int’l Co., 550 U.S. at 416, 127 S.Ct. 1727). Under relevant Federal Circuit precedent, the prior art “teaches away” if a person having ordinary skill, “upon reading the reference, would be discouraged from following the path set out in the reference, or would be led in a direction divergent from the path that was taken by the applicant.” In re Gurley, 27 F.3d 551, 553 (Fed.Cir.1994). For a reference to teach away, it must state more than a general preference for an alternative invention. It must “criticize, discredit, or otherwise discourage” investigation into the invention claimed. In re Fulton, 391 F.3d 1195, 1201 (Fed.Cir.2004). In light of the above standard, the Court finds that the prior art taught away from the use of a hydrophilic group at the 4-position of the imidazole ring. The prior art evidences more than a general preference for the use of a lipophilic substituent at the 4-position, clearly discouraging a person of ordinary skill from using a hydrophilic group at this position. This clear discouragement is established by the overwhelming weight of the art, specifically language found in the '069 patent, the emphasis on lipophilicity at the 4-position in DuPont’s second generation ARB compounds, DuPont SAR data from the '069 patent, and the use of lipophilic substituents at the 4-position in other second generation compounds. a. Language Found in the '069 Patent The '069 patent, itself, contains language which would discourage a person of ordinary skill from using a hydrophilic substituent at the 4-position of the imidazole ring. The '069 patent expresses a preference for a lipophilic group at the 4-position as demonstrated by a regioisomer comparison. The '069 patent states that: “[i]n all series examined, the more rapidly eluted isomer of a given pair has greater biological potency then the less rapidly eluted isomer.” (PTX 195, at JA 10093.) The patent goes on to define the “more rapidly eluted isomer” as a compound with an imidazole ring containing a lipophilic chlorine atom at the 4-position of the imidazole ring, and the “less rapidly eluted isomer” as a compound with a hydroxymethyl (CH2OH) at the 4-position. (Id.) Of the over 400 compounds released in the '069 patent, the hydroxymethyl referenced in this statement is one of the most hydrophilic. (Timmermans 4/16/09 Tr. JA 1366:24-1367:1; Weinstock 4/1/09 Tr. JA 185:17-25.) The compound containing the hydroxymethyl also has the least potency as compared to losartan. (Weinstock 4/1/09 Tr. JA 185:17-25.) Based on this statement alone, a person of ordinary skill in the art, upon reading this language, would have been discouraged from using a hydrophilic group at the 4-position. b. Lipophilicity in DuPont’s Second Generation Compounds The preference for a lipophilic substituent at the imidazole ring’s 4-position is further demonstrated by DuPont’s second generation ARB development. Following DuPont’s success with losarían, the company engaged in additional research to create an improved antihypertensive. (Lipinski 4/20/09 Tr. JA 1559:8-13; Weinstock 4/6/09 Tr. JA 517:3-22.) As a result of this research, DuPont developed two second generation ARBs — DuP 532 and the '902 patent compounds. These second generation compounds not only shared losartan’s structural backbone, but also enhanced losartan’s antihypertensive properties by increasing lipophilicity at the 4r-position of the imidazole ring. (Lipinski 4/20/09 Tr. JA 1559:2-7,1677:18-20.) DuP 532 and the '902 patent compounds modified the chlorine atom at the 4-posi-tion of the imidazole ring in favor of more lipophilic compounds. (Weinstock 4/1/09 Tr. JA 213:3-6, 216:8-10.) DuP 532 employed a more lipophilic substituent containing multiple fluorine atoms (CF2CF3), while the '902 patent compounds contained a series of more lipophilic alkyl substituents, including methyl, ethyl, isopropyl, and t-butyl. (Id.) Based on these changes, DuP 532 and the '902 patent compounds exhibited better antihypertensive activity than losarían. (Lipinski 4/20/09 Tr. JA 1577:11-15.) By making the 4-position more lipophilic, DuP 532 generated a three-fold increase in oral activity over losartan. (Timmermans 4/16/09 Tr. JA 1391:12-16; Lipinski 4/20/09 Tr. JA 1577:11-15.) The most preferred compounds in the '902 patent — Examples 1, 2, and 4 — exhibited “oral antihypertensive activity approximately 2 to 4 fold higher than the most active compounds specifically disclosed [in the '069 patent] which have been tested.” (DTX 96, at JA 3748.) At trial, both parties’ medicinal chemistry experts emphasized the importance of lipophilic type binding forces in the '902 patent compounds. Mylan’s medicinal chemistry expert, Dr. Joseph Weinstock, acknowledged that “lipophilicity is ... an important part of this patent.” (Weinstock 4/1/09 Tr. JA 218:19.) He further agreed that: the '902 patent teaches that a lipophilic but not an electron-withdrawing group, at the 4-position of the imidazole gives compounds with potent binding activity and are orally active ... [which] ... emphasizes the importance of lipophilictype binding forces between the surface of the antagonist and the receptor. (Id. at JA 218:12-15, 220:1-3.) Likewise Daiichi Sankyo’s expert in medicinal chemistry, Dr. Christopher Lipinski, opined that “the '902 patent confirms the preference for lipophilic groups at the 4-posi-tion.” (Lipinski 4/20/09 Tr. JA 1559:14-16.) c. DuPont’s SAP from the '069 Patent DuPont’s SAR from the '069 patent also evidences a preference for lipophilic substituents at the 4-position of the imidazole ring. This data confirms that lipophilic substituents at the 4-position exhibited the best binding affinity. The '069 patent disclosed the specific binding affinity data for over 200 compounds. (Weinstock 3/31/09 Tr. JA 119:19-20; PTX 195, at JA 10213-215.) The vast majority of the '069 patent compounds contains lipophilic substituents at the 4-position. (Lipinski 4/20/09 Tr. JA 1555:8-10.) Of the forty-two compounds tested with a biphenyl tetrazole structure, thirty-six have lipophilic substituents at the 4-position, four use hydrophilic substituents, and two contain a neutral substituent. (Id. at JA 1649:7-1650:21.) A subseries analysis of lipophilic and non-lipophilic compounds from the '069 patent illustrates a preference for lipophilicity. By looking at compounds with identical 1-, 2-, and 5-positions and varied 4-positions, Dr. Lipinski and Daiiehi Sank-yo’s second medicinal chemistry expert Dr. Pieter Timmermans concluded that the advantage of lipophilicity is evidenced across all subseries, including non-biphenyl tetrazole series. (Timmermans 4/16/09 Tr. JA 1376:9-22, 4/17/09 JA 1530:3-6; Lipinski 4/20/09 Tr. JA 1556:18-21.) As stated by Dr. Timmermans, a comparison amongst subseries taught that a medicinal chemist could “make very potent molecules if you put a large lipophilic group on the 4-position compared to neutral, perhaps or more importantly, hydrophilic groups.” (Timmermans 4/16/09 Tr. JA 1376:9-22.) In rebuttal, Mylan points to six compounds in the '069 patent with high binding affinities and neutral or hydrophilic groups at the 4-position. (Weinstock 4/1/09 Tr. JA 233:13-17.) Mylan argues that these compounds, which equal roughly 1% of the disclosed compounds in the '069 patent, suggest the use of a hydrophilic group at the 4-position, because two of these compounds exhibited binding affinities that exceeded losarían. (Lipinski 4/20/09 Tr. JA 1651:2-9; DTX 256-A at JA 5157, 415-C at JA 5298.) However, a placement of these six compounds in their respective subseries confirms the importance of lipophilicity for best binding activity. For each non-lipophilic compound highlighted by Mylan, the '069 patent provides a comparable compound with identical 1-, 2-, and 5-positions but with a lipophilic group at the 4-posi-tion. (PTX 628-2, at JA 25115.) In each instance, the compound containing a lipophilic 4-position exhibited better binding activity. (Weinstock 4/1/09 Tr. JA 260:13-19.) This same emphasis is highlighted by a comparison of regioisomer pairs in the '069 patent. As both parties’ experts agreed, an analysis of paired compounds, or “regioisomer” pairs, with two positions switched gives helpful information about the SAR at these positions. (Weinstock 4/6/09 Tr. JA 510:24-511:6; Lipinski 4/20/09 Tr. JA 1557:10-13.) The '069 patent contains several sets of regioisomer pairs with swapped 4-and 5-positions of the imidazole ring — the 7711 Series and the Tetrazole Series. (Timmermans 4/16/09 Tr. JA 1338:13-17.) The Tetrazole Series contains the data and structure of two regioisomer pairs that use a biphenyl tetrazole at the 1-position, including losarían and its regioisomer Example 118. Figure 6 The Tetrazole Series. (PTX 627, at J A 25113.) In this set, losartan exhibited better in vitro activity than Example 118, as demonstrated by lower 1050 values. (Id.) Losartan exhibited a binding affinity of 0.039 mg/kg, while the hydrophilic Example 118 showed a binding affinity of 0.089 mg/kg. (Id.) Likewise, in the 7711 Series, Example 94 and Example 102 both contained lipophilic substituents at the 4-position and hydrophilic substituents at the 5-position. Conversely, Examples 95 and 105 both have hydrophilic substituents at the 4-position and lipophilic substituents at the 5-position. (Id.) In both sets, the compound with the lipophilic substituent at the 4-position had a lower IC60 value, and thus better activity. Example 94 exhibited a binding affinity of 0.28 mg/kg, while its regioisomer, Example Example 94 exhibited a binding affinity of 0.28 mg/kg, while its regioisomer, Example 95, had a binding affinity of 1.2 mg/kg. Example 102 possessed a binding affinity of 0.061 mg/kg, while its regioisomer, Example 105, had a binding affinity of 0.68 mg/kg. (Id.) Mylan refutes Daiiehi Sankyo’s regioisomeric analysis by reference to a July 1990 article titled “Nonpeptide Angiotensin II Receptor Antagonists” by Johnson et al. (“Johnson Article”). (PTX 224, at JA 10708.) The Johnson Article concluded that the “electron withdrawing” substituent at the 4-position would be useful in increasing oral activity, while the substituent at the 5-position may be “capable of hydrogen bonding.” (Id.) Mylan maintains that in each regioisomeric pair cited above, the compounds with the greater binding affinity possessed an electron withdrawing substituent at the 4-position and a substituent capable of hydrogen bonding at the 5-position. (PTX 624-25, at JA 25110-111; DTX 132, at JA 4255.) After swapping the substituents at the 4-and 5-posi-tions, Mylan claims that the substituent at the 4-position was not electron withdrawing and the substituent at the 5-position was not capable of hydrogen bonding, thereby lowering binding affinities. Mylan’s interpretation, however, is contradicted by express language of the '069 patent discussed above. The '069 patent states: “In all series examined, the more rapidly eluted [more lipophilic] isomer of a given pair has a greater biological potency than the less rapidly eluted [less lipophilic] isomer.” (PTX 195, at 10093.) d. Other Second Generation ARB Compounds Beyond DuPont’s extensive ARB work, research related to other second generation compounds evidenced the advantage of a lipophilic group at the 4-position of the imidazole ring. L-158,809, the Eisai compounds, eandesartan cilexetil, and valsarían all used losarían as a lead and contain a lipophilic substituent at the 4-position or the 4-position’s equivalent. (Lipinski 4/20/09 Tr. JA 1562:21-1563:3.) Dr. Weinstock even admitted that researchers, working prior to olmesartan medoxomil’s priority date, “followed the teaching of lipophilicity at the 4-position” to discover irbesartan with a lipophilic 4-position. (Weinstock 4/6/09 Tr. JA 533:6-534:4.) Mylan points to other second generation compounds as described in an October 1992 non-prior art patent review titled “Angiotensin-II Antagonists: Patent Activity since the Discovery of DuP 753” by Peter Bhlmayer, as evidence that second generation compounds used hydrophilic substituents at the 4-position. (PTX 167, at JA 9848-879.) However, for purposes of the teaching away doctrine, only publications which qualify as prior art references may be considered. See In re Gurley, 27 F.3d at 553 (stating that a “reference” teaches away “when a person of ordinary skill, upon reading the reference, would be discouraged from following the path set out in the reference, or would be led in a direction divergent from the path that was taken by the applicant.”) Even assuming that this article qualifies as prior art, the majority of the compounds in this paper contain a lipophilic group at the 4-position. (PTX 167, at JA 9848-879.) The publication identifies “best known” compounds, which list prior art compounds containing lipophilic groups. (Id.; Lipinski 4/20/09 Tr. JA 1585:15-1586:7.) The one exception is eprosartan, which employs a neutral substituent hydrogen (H) at the 4-position. (Lipinski 4/20/09 Tr. JA 1586:8-1587:4; PTX 712, at JA 25191.) When viewed in total, the express language of the '069 patent, DuPont’s development of its second generation ARB compounds, DuPont’s SAR, and the structure of other second generation compounds indicate that the prior art showed more than a general preference for lipophilic groups at the 4-position. Based on this prior art, the Court finds that a person of ordinary skill would have been discouraged from using a hydrophilic substituent at this position. D. Differences between the Claimed Subject Matter and Prior Art Turning to the third Graham factor, the Court must examine the differences between the claimed subject matter and prior art. When the patent at issue involves a chemical compound, the differences between the claimed invention and the prior art often “turn[ ] on the structural similarities and differences between the claimed compound and the prior art.” Eisai Co. Ltd. v. Dr. Reddy’s Labs., Ltd., 533 F.3d 1353, 1356-57 (Fed.Cir.2008). “[Structural similarity between claimed and prior art subject matter ... where the prior art gives reason or motivation to make the claimed compositions, creates a prima facie case of obviousness.” Takeda, 492 F.3d at 1356. “[I]t remains necessary to identify some reason that would have led a chemist to modify a known compound in a particular manner to establish prima facie obviousness of a new claimed compound.” Id. at 1357 (citation omitted); see also Proctor & Gamble Co. v. Teva Pharms. USA, Inc., 566 F.3d 989, 994 (Fed.Cir.2009); Eisai Co., 533 F.3d at 1357. The requisite motivation can come from any number of sources and need not necessarily be explicit in the art. Eisai Co., 533 F.3d at 1357 (citing Aventis Pharma Deutschland GmbH v. Lupin, Ltd., 499 F.3d 1293, 1301 (Fed.Cir.2007)). Instead, “it is sufficient to show that the claimed and prior art compounds possess a ‘sufficiently close relationship ... to create an expectation,’ in light of the totality of the prior art, that the new compound will have ‘similar properties’ to the old.” Id. at 1357 (quoting In re Dillon, 919 F.2d 688, 692 (Fed.Cir.1990) (en banc)). 1. Selection of Lead Compound An obviousness argument based on structural similarity between claimed and prior art compounds “depends on a preliminary finding that one of ordinary skill in the art would have selected [the prior art compound] as a lead compound.” Takeda, 492 F.3d at 1357; see also Eisai Co., 533 F.3d at 1359 (stating that “post-KSR, a prima facie case of obviousness for a chemical compound still, in general, begins with the reasoned identification of a lead compound” in the prior art). The prior art may point to more than a “single lead compound for development efforts.” Altana Pharma AG v. Teva Pharms. USA, Inc., 566 F.3d 999, 1008 (Fed.Cir.2009). Even so, a compound will be found non-obvious if “the prior art disclose[s] a broad selection of compounds any one of which could have been selected as a lead for further investigation.” Takeda, 492 F.3d at 1359-60. A lead compound is defined as a compound with known properties that a medicinal chemist uses as a starting point for drug development. (Weinstock 3/31/09 Tr. JA 84:5-85:12.) When selecting a lead point for development, a medicinal chemist of ordinary skill considers a multitude of factors, including the lead compound’s potency. (Lipinski 4/20/09 Tr. JA 1582:12-19; Weinstock 3/31/09 Tr. JA 87:25-88:4.) In addition, a medicinal chemist looks for compounds with robust packages of real data, such as binding activity, intravenous activity, oral activity, specificity, and multiple species testing. (Lipinski 4/20/09 Tr. JA 1561:10-1562:10; PTX 703-1, at JA 25172.) Turning to the instant matter, Mylan maintains that a person of ordinary skill in the art would have selected the six compounds from the '902 patent as leads. (Weinstock 3/31/09 Tr. JA 127:2-21.) The company contends the '902 patent represented a continuation of DuPont’s work on losartan and other '069 patent compounds, as evidenced by the fact that the '902 patent explicitly stated that the most preferred compounds “exhibit[ed] remarkable and unexpected potency as antihypertensives” with “oral antihypertensive activity approximately 2 to 4 fold higher than the most active compounds [of the '069 patent] which have been tested.” (DTX 96, at JA 3748.) Mylan asserts that a person of ordinary skill in the art would have selected the '902 patent compounds to take advantage of the “wealth” of SAR data from structurally similar '069 patent compounds and would have been confident in the safety of the '902 patent compounds since losartan was in clinical trials. (Lipinski 4/20/09 Tr. JA 1686:23-24; Weinstock 3/31/09 Tr. JA 127:2-21.) Even accepting these arguments as true, Mylan has not established by clear and convincing evidence that a person of ordinary skill would have selected the '902 patent compounds out of the numerous other second generation ARBs disclosed in the prior art. At the time of olmesartan medoxomil’s priority date, the public had access to substantial data related to L-158,809, DuP 532, the Eisai compounds, and valsarían. Merck and DuPont released data related to the binding affinity, intravenous activity, oral activity, and selectivity of L-158,809 and DuP 532. (Lipinski 4/20/09 Tr. JA 1570-77.) Eisai disclosed data relating to the Eisai compounds’ binding affinity and intravenous activity, and Ciba-Geigy revealed information about valsartan’s binding affinity, intravenous activity, and oral activity. (Id. at JA 1577-81.) In contrast, DuPont failed to report any additional data related to the '902 patent compounds. (Id. at JA 1566-69.) Moreover, even if the '902 patent compounds exhibited “antihypertensive activity approximately 2 to 4 fold higher than the most active compounds” of the '069 patent, this improvement is at most comparable to other second generation ARBs. In terms of binding affinity, L-158,809 had 180 times, Example 7 of the Eisai compounds had 100 times, DuP 532 had seven times, and valsarían had two times the potency of losartan. (Lipinski 4/20/09 Tr. JA 1571:7-11, 1580:18-21.) DuP 532 even evidenced three times the oral activity of losartan and L-158,809 expressed almost perfect bioavailability. (Id. at JA 1576:24-1577:2.) Based on this data, Dr. Weinstock admitted on cross-examination that L-158,809 and DuP 532 were significantly more potent than losartan. (Weinstock 4/6/09 Tr. JA 529:10-531:9.) The '902 patent compounds were not the only second generation ARBs that could rely on the “wealth” of DuPont’s SAR data. Just like the '902 patent compounds, DuP 532 shared losartan’s imidazole-biphenyl-tetrazole backbone. (Id. at JA 1677:12-14.) A person of ordinary skill who chose DuP 532 or the '902 patent compounds as leads would have had access to this data when developing an antihypertensive equivalent to olmesartan medoxomil. (Id. at JA 1686:23-24.) In light of the foregoing, Mylan has failed to prove by clear and convincing evidence that a person of ordinary skill in the art would have selected the '902 patent compounds over other second generation ARBs. Since a person of ordinary skill in the art could have selected a lead compound from a “broad selection of compounds,” Mylan has failed to establish its prima facie case of obviousness. 2. Structural Differences between Lead Compound and Olmesartan Medoxomil Even assuming that Mylan established by clear and convincing evidence that a medicinal chemist of ordinary skill would have selected the '902 patent compounds as leads, these compounds differ structurally from olmesartan medoxomil in several respects. At the 4-position of the imidazole ring, the '902 patent compounds employ various branched alkyls, including an ethyl, methyl, t-butyl, and isopropyl. Olmesartan medoxomil uses a hydroxyisopropyl. (DTX 356-A, at JA 5143.) The various alkyls in the '902 patent compounds belong to the alkane class of compounds and enjoy lipophilic properties. (Lipinski 4/20/09 Tr. JA 1589:22-25, 1626:5-1627:3.) Hydroxyisopropyl, found in olmesartan medoxomil, is formed by adding a hydroxyl (OH) to an isopropyl, transforming the lipophilic alkane isopropyl into a hydrophilic alcohol. (Id. at JA 1625:24-1626:9.) This change results in opposing chemical properties. The lipophilic alkanes found in the '902 patent compound possess low solubility in water and lack the ability to form hydrogen bonds. (PTX 719, at JA 25196.) Conversely, the hydrophilic hydroxyisopropyl used in olmesartan medoxomil forms hydrogen bonds and exhibits high solubility in water. (Id.) The character of the alkyl and alcohol groups remain constant in both small and large compounds. (Lipinski 4/20/09 Tr. JA 1627:5-9.) As recognized by the patent examiner of olmesartan medoxomil, the addition of the hydroxyl was a “critical” structural difference, which distinguished olmesartan medoxomil from the '902 patent compounds. (PTX-4, at JA 8846.) Mylan maintains that the '902 patent compounds and olmesartan medoxomil were structurally similar at the 4-position by virtue of intramolecular hydrogen bonding. (Weinstock 4/6/09 Tr. JA 534:13-20.) This bonding caused the hydroxyisopropyl to act like a lipophilic alkane, creating a structure similar to the '902 patent compounds. Even assuming that such intramolecular bonding occurred, Dr. Weinstock admitted that the '902 patent compounds and olmesartan medoxomil would differ under such circumstances. Intramolecular hydrogen bonding would transform olmesartan at the 4-and 5-positions of the imidazole ring. (Weinstock 4/6/09 Tr. 52:25-53:3; Yanagisawa 4/17/09 Tr. 84:8-19.) This bonding would create a new ring structure that “would certainly differ in structure from losartan ... and the '902 compounds.” (Weinstock 4/6/09 Tr. 53:4-10; Lipinski 4/20/09 Tr. 66:20-67:1; PTX 725.) Moreover, at the time of olmesartan medoxomil invention, a person of ordinary skill in the art would not have conceived of this type of bonding. Dr. Yanagisawa’s post-priority date paper titled “Nonpeptide Angiotensin II Receptor Antagonists: Synthesis, Biological Activities, and Structure-Activity Relationships of Imidazole5-carboxylic Acids Bearing Alkyl, Alkenyl, and Hydroxyalkyl Substituents at the 4-Position and Their Related Compounds” was the first paper in the ARB art to mention intramolecular hydrogen bonding. Dr. Yanagisawa speculated that this type of bonding “might account for the potent activities of and the compounds having a hydroxyalkyl group at the 4-position.” (PTX 26, at JA 9555.) If a person of ordinary skill used a hydrophilic group to act as a lipophilic group, such a decision would not have been obvious to a person skilled in the art. Instead, such a decision would have been “pretty inventive.” (Lipinski 4/20/09 Tr. JA 1613:15-20.) Turning to the 5-position of the imidazole ring, olmesartan medoxomil and the '902 patent compounds also differ. Olmesartan medoxomil is a prodrug that contains a carboxylic acid linked to a medoxomil ester at this position. (Lipinski 4/20/09 Tr. JA 1616:1-2.) Unlike olmesartan medoxomil, Examples 1, 2, and 6 of the '902 patent compounds use a carboxylic acid at the 5-position, while Examples 3, 4, and 5 employ an aldehyde (CHO). (Id at JA 1616:1-2.) Notably, in 1994, DuPont attempted to create a medoxomil pro drug for Example 2 of the '902 patent compounds, resulting in a three-fold decrease in oral activity. (Hieble 4/7/09 Tr. JA 765:14-766:25; Timmermans 4/16/09 Tr. JA 1397:16-1398:1.) DuPont’s failed attempt at transforming Example 2 into a prodrug highlights the significant difference in overall structure between olmesartan medoxomil and the '902 patent compounds. 3. Reason or Motivation to Make the Specific Modifications Necessary to Achieve Olmesartan Medoxomil Assuming that the '902 patent compounds would have been selected as lead compounds and that a structural similarity existed between the '902 patent compounds and olmesartan medoxomil, Mylan still fails to prove by clear and convincing evidence that a person of ordinary skill in the art would have been motivated to modify the 4-and 5-positions of the '902 patent compounds to derive the invention at issue, a. Motivation to Make a Specific Modification to the imposition of the Imidazole Ring Mylan argues that a medicinal chemist of ordinary skill would have been motivated to modify the lipophilic alkyls found at the 4-position of the '902 patent compounds based on a compound revealed in the '069 patent, Example 118. Besides being the regioisomer of losartan, Example 118 was one of the “more potent” compounds in the '069 patent. (Timmermans 4/17/09 Tr. JA 1532:10-14.) Example 118 employed a hydrophilic hydroxymethyl substituent at the 4-position of the imidazole ring and a chlorine at the 5-position. (DTX 356-A, at JA 5151.) According to Mylan, a person of ordinary skill would have changed the 4-posi-tion of the '902 patent compounds, because the '902 patent taught that the 4-position did not require electron-withdrawing substituents by virtue of the fact that these compound employed non-electron withdrawing branched alkyls. (Weinstock 4/1/09 Tr. JA 216:11-17; Yanagisawa 4/17/09 Tr. JA 1467:17-1468:4.) This contradicted the Johnson Article’s teaching, which stated that an electron withdrawing substituent at the 4-position may improve oral absorption. (DTX 132, at JA 4255.) Based on this contradiction, Mylan argues that a person of ordinary skill would have scanned DuPont’s SAR from the '069 patent and deduced that a non-electron withdrawing substituent such as olmesartan medoxomil’s hydroxyisopropyl was needed at the 4-position. This medicinal chemist of ordinary skill then would have utilized bioisosterism or the “principal of minor modifications” to transform the alkyls of the '902 patent compounds into a hydroxyisopropyl. This argument fails for several reasons. First, as discussed above, the prior art taught away from the use of a hydrophilic substituent, such as a hydroxyisopropyl, at the 4-position. When the prior art teaches a preference for substituents with opposite properties, the invention at issue is not obvious. See Eisai Co., 533 F.3d at 1355-57 (finding a chemical compound non-obvious where the invention at issue replaced a more lipophilic substituent with a less lipophilic substituent in contravention of the prior art’s teaching that lipophilicity at a particular position on a ring structure conferred beneficial results). Since the prior art taught away from the use of a hydrophilic substituent at the 4-position, a person of ordinary skill would not have been motivated to change the lipophilic alkyls in the '902 patent compounds to the hydrophilic hydroxyisopropyl found in olmesartan medoxomil. Second, a person of ordinary skill in the art would not select the '902 patent compounds as leads only to disregard one of their distinguishing characteristics, specifically their increased lipophilicity at the 4-position. The Federal Circuit has found that a chemical compound is not obvious when the “record ... shows no discernible reason for a skilled artisan to begin with [a lead] only to drop the very feature ... that gave this advantageous property [for which the lead was selected.]” Id. at 1358. As described above, Mylan contends that a person of ordinary skill in the art would have selected the '902 patent compounds over other second generation compounds, since these compounds exhibited “oral antihypertensive activity approximately 2 to 4 fold higher than the most active compounds [of the '069 patent] which have been tested.” (DTX 96, at JA 3748.) Both parties acknowledge that the branched alkyls at the 4-position of the '902 compounds were more lipophilic than the chlorine found at the 4-position of losartan and Dr. Weinstock emphasized the importance of lipophilic type binding forces in the '902 patent compounds. (Weinstock 4/1/09 Tr. JA 219:19-220:17.) He explicitly stated that “lipophilicity is ... an important part of this patent.” (Weinstock 4/1/09 Tr. JA 218:17-19.) If a person of ordinary skill would have selected the '902 patent compounds over other potential leads because of their increased potency, the Court finds it illogical to con-elude that the same hypothetical person would then quickly turn around and modify the 4-position to achieve the patent at issue. A person of ordinary skill would not alter an “advantageous part” of the '902 patent compounds for a hydrophilic substituent with opposing chemical properties. Such a decision would lack an obvious basis to, one skilled and the art, and only could be considered non-obvious in light of the record presented at trial. b. Motivation to Make a Specific Modification to the 5-position of the Imidazole Ring There is also scant evidence that a person of ordinary skill would be motivated to modify the 5-position of the '902 patent compounds to a carboxylic acid linked to a medoxomil acid. While Examples 2 and 6 of the '902 patent compounds contain a carboxylic acid, Examples 1, 3, 4, and 5 contain an aldehyde. (PTX 701, at JA 25170; DTX 96, at JA 3751.) The '902 patent compounds exhibited a preference for an aldehyde at the 5-posi-tion. Two out of the three most preferred compounds in the '902 patent compounds use an aldehyde and not a carboxylic acid, suggesting to a person of ordinary skill that “there was something good” about this substituent. (Lipinski 4/20/09 Tr. JA 1615:17-21.) Dr. Lipinski opined that “based on first principals” you would expect better oral activity with the aldehyde, as opposed to the carboxylic acid. (Id. at JA 1615:22-25.) Even if a person of ordinary skill focused on Examples 2 and 6, which contained a carboxylic acid at the. 5-position, Mylan does not establish by clear and convincing evidence that such a person would have been motivated to transform the '902 patent compounds into a prodrug. When designing prodrugs, medicinal chemists overcome a whole series of “hurdles.” (PTX 718, at JA 25195.) Pharmaceutical companies “avoid prodrugs” because “there are problems in ... determining whether the prodrug itself has pharmacology” and “whether the conversion of the prodrug to [the] active [form] is reproducible.” (Hieble 4/7/09 Tr. JA 761:21-763:1.) As of April 26, 1991, medicinal chemists approached the creation of a prodrug as a “last resort,” “a desperation, last-ditch approach,” which was unpredictable. (Lipinski 4/20/09 Tr. JA 1623:2-5.) Moreover, if a person of ordinary skill would have employed a prodrug, there is little evidence that such a person would have selected the promoiety medoxomil. As acknowledged by Mylan’s expert Dr. J. Paul Heible, medicinal chemists infrequently use medoxomil. (Hieble 4/7/09 Tr. JA 761:10-12.) While Daiichi Sankyo employed medoxomil in various other antihypertensives and antibiotics, there is no evidence in the prior art that medicinal chemists successfully applied medoxomil in the ARB context prior to olmesartan medoxomil. Indeed, in 1994, DuPont attempted to make a medoxomil prodrug for Example 2 of the '902 patent, and failed. Adding the medoxomil ester to Example 2 resulted in a compound three times less potent than Example 2 itself. (Id. at JA 765:14-766:25; Timmermans 4/16/09 JA 1397:16-1398:1; PTX 175, at JA 9910.) 4. Reasonable Expectation of Obtaining Olmesartan MedoxomilOs Properties Additionally, Mylan has not proven by clear and convincing evidence that a person of ordinary skill in the art would have had a “reasonable expectation of success” in obtaining olmesartan medoxomil’s properties. PharmaStem Therapeutics, Inc. v. ViaCell, Inc., 491 F.3d 1342, 1360 (Fed.Cir.2007); Proctor & Gamble, 566 F.3d at 996. In KSR Intern. Co. v. Teleflex Inc., 550 U.S. 398, 402, 127 S.Ct. 1727, 167 L.Ed.2d 705 (2007), the Supreme Court stated that when an obvious modification “leads to the anticipated success,” the invention is likely the product of ordinary skill and is obvious. “[0]bviousness cannot be avoided simply by a showing of some degree of unpredictability in the art so long as there was a reasonable probability of success.” Pfizer, 480 F.3d at 1364 (citing In re Corkill, 771 F.2d 1496, 1500 (Fed.Cir.1985)). Here, a person of ordinary skill in the art would not have “reasonably expected” that modifying the 4-position of the imidazole ring from a lipophilic to a hydrophilic substituent would have lead to increased oral activity and binding affinity. The pri- or art taught that a lipophilic alkyl group at the 4-position provided better potency than a hydrophilic hydroxyalkyl group at the same position. (Lipinski 4/20/2009 Tr. JA 1625:12-15.) Based on this teaching, a person of ordinary skill would have expected olmesartan medoxomil to exhibit decreased binding activity and decreased oral activity even when compared to first generation ARBs like losartan. Instead, olmesartan medoxomil displayed high activity in binding affinity tests when administered intravenously and orally. In terms binding affinity, olmesartan medoxomil exhibited 470 times the potency of losartan. For oral and intravenous activity, olmesartan medoxomil showed 40 times the potency intravenously and 100 times the potency orally when compared to losartan. (PTX 26, at JA 9556, PTX 63, at JA 9676, PTX 676, at JA25164; Hieble 4/7/09 Tr. JA 672:8-19; Fink 4/16/09 Tr. JA 1238:9-1239:16.) Since the '902 patent compounds “exhibit[ed] remarkable and unexpected potency as antihypertensives” when compared to losartan, a person of ordinary skill would have also expected reduced activity from compounds with a hydrophilic group at the 4-position of the '902 patent compounds. (DTX 96, at JA 3748; Lipinski 4/20/2009 Tr. JA 1628:7-11.) In total, Mylan has failed to establish a prima facie case of obviousness. Mylan has not proven by clear and convincing evidence that a person of ordinary skill would have selected the '902 patent compounds as lead, that the '902 patent compounds are structurally similar to olmesartan medoxomil, that a person of ordinary skill would have been motivated to modify the 4-and 5-positions of the imidazole ring, or that a person of ordinary skill would have reasonably expected to obtain olmesartan medoxomiFs properties. As such, Claim 13 of the '599 patent, which covers olmesartan medoxomil, is not invalid for obviousness. E. Secondary Considerations of Non-Obviousness Assuming arguendo that Mylan established a prima facie case of obviousness, secondary considerations further mitigate against a finding of obviousness. Objective indicia of non-obviousness include: (1) unexpected results; (2) commercial success; (3) long felt, unmet need; (4) copying; and (5) industry praise and recognition for the inventions. Graham, 383 U.S. at 17, 86 S.Ct. 684. Secondary considerations extend beyond what was known at the time of the invention and may include later discovered unexpected properties of the invention. Knoll Pharm. Co., Inc. v. Teva Pharms. USA, Inc., 367 F.3d 1381, 1385 (Fed.Cir.2004). When reaching the ultimate conclusion of obviousness, courts rely on secondary considerations as part of the “totality of the evidence.” Richardson-Vicks Inc. v. Upjohn Co., 122 F.3d 1476, 1483 (Fed.Cir.1997). These considerations often represent “the most probative and cogent” evidence in the record. Stratoflex, Inc. v. Aeroquip Corp., 713 F.2d 1530, 1538 (Fed.Cir.1983). Even so, “they do not control the obviousness conclusion.” Newell Cos., Inc. v. Kenney Mfg. Co., 864 F.2d 757, 768 (Fed.Cir.1988). As demonstrated by Daiichi Sankyo, several secondary considerations weigh against a finding of obviousness, specifically unexpected results and commercial success. 1. Unexpected Results Evidence of “unexpected results” allows a patent-holder to rebut a prima facie case of obviousness by showing that the “claimed invention exhibits some superior property or advantage that a person of ordinary skill in the relevant art would have found surprising or unexpected.” In re Soni, 54 F.3d at 750. The reasoning behind this secondary consideration is straightforward: “that which would have been surprising to a person of ordinary skill in a particular art would not have been obvious.” In re Mayne, 104 F.3d 1339, 1343 (Fed.Cir.1997). To qualify as unexpected, the claimed properties or results must be different in “kind and not merely in degree” from the results of the prior art. In re Huang, 100 F.3d 135, 139 (Fed.Cir.1996). “[W]hen unexpected results are used as evidence of nonobviousness, the results must be shown to be unexpected compared with the closest prior art.” In re Baxter Travenol Labs., 952 F.2d 388, 392 (Fed.Cir.1991). Daiichi Sankyo contends that olmesartan medoxomil exhibited unexpected blood pressure lowering ability as compared to the '902 patent compounds. More precisély, the patent holder argues that olmesartan medoxomil showed an unexpected result by lowering blood pressure one to two millimeters of mercury (mm Hg) more than the other ARBs on the market. Whether or not olmesartan medoxomil lowers blood pressure unexpectedly more is subject to some dispute between the parties. The Court need not address this issue, however, since it finds that olmesartan medoxomil exhibits unexpected results as compared to the '902 patent compounds in terms of potency, drug-drug interactions, insurmountable antagonism, inverse agonism, and other rehabilitative properties. With regards to potency, a medicinal chemist of ordinary skill would have considered a two to four fold increase in intravenous and oral potency over the '902 patent compounds as unexpected. (Fink 4/16/09 Tr. JA 1237:14-21.) The '902 patent explicitly states that the most preferred compounds “exhibited] remarkable and unexpected potency as antihypertensives” and have “oral antihypertensive activity approximately 2 to 4 fold higher than the most active compounds [of the '069 patent] which have been tested.” (DTX 96, at JA 3748) (emphasis added). If the '902 patent compound exhibited “remarkable and unexpected” potency in relation to compounds